Recommended Products
species reactivity
human
Quality Level
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
General description
Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for investigators involved with this rapidly expanding field of study. The alpha5beta1 Investigator kit is designed for research focused specifically on the alpha5beta1 integrin.
Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.
Chemicon offers the Integrin alpha5beta1 Investigator Kit for initial studies of alpha5beta1 interactions. All kit reagents are also available in larger sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.
Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.
Chemicon offers the Integrin alpha5beta1 Investigator Kit for initial studies of alpha5beta1 interactions. All kit reagents are also available in larger sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.
Application
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
Components
alpha5 Mouse Monoclonal Antibody (Part No. MAB1956Z-20) - 1 tube, 20 μg.
beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20) - 1 tube, 20 μg.
alpha5beta1 Mouse Monoclonal Antibody (Part No. MAB1999-20) - 1 tube, 20 μg.
Purified alpha5beta1 Protein (Part No. CC1052-10) - 1 tube, 10 μg.
beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20) - 1 tube, 20 μg.
alpha5beta1 Mouse Monoclonal Antibody (Part No. MAB1999-20) - 1 tube, 20 μg.
Purified alpha5beta1 Protein (Part No. CC1052-10) - 1 tube, 10 μg.
Physical form
Chemicon′s alpha5beta1 Integrin Investigator Kit provides researchers with an economical way of performing investigative research on the alpha5beta1 integrin. This kit provides 20 μg each of monoclonals to alpha5, beta1, alpha5beta1, and 10 μg o
Storage and Stability
Store antibodies at -20°C and the purified integrin protein at -70°C.
Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop cent
Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop cent
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
Storage Class Code
12 - Non Combustible Liquids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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