5.08514

Psalmotoxin-1

• Synonym(s): Psalmotoxin-1, ASIC1a Inhibitor, Psalmotoxin 1
• Empirical Formula (Hill Notation): C₂₀₀H₃₁₂N₆₂O₅₇S₆
• CAS Number: 316808-68-1
• Molecular Weight: 4689.39
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥94% (HPLC)
• Quality Level: 100
• form: semisolid; viscous liquid
• potency: 0.9 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: colorless
• storage temp.: −20°C

Description

General description

A potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC₅₀ = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.

Biochem/physiol Actions

Primary Target
ASIC1a

Warning

Toxicity: Standard Handling (A)

Sequence

EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)

Other Notes

Qadri, Y. J. et al. 2009. J. Biol. Chem.284, 17625.
M. Mazzuca, et al. 2007. Nat Neurosci.10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem.275, 25116.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable