23-044-M
VHL Protein Complex, Active, 10 µg
Active complex of five (5) recombinant human enzymes: VHL amino acids 54-end, full length Elongin C, full length Elongin B, full length Cul2, & full length Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
Synonym(s):
VCB-Cul2 complex, ECV complex, CBC VHL
About This Item
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biological source
human
Quality Level
recombinant
expressed in Sf21 cells
form
liquid
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable
solubility
water: soluble
NCBI accession no.
Gene Information
human ... Cul2(8453) , Rbx1(9978) , VHL(7428)
General description
The von-Hippel Lindau tumor suppressor (VHL) complex is a multi-subunit ubiquitin ligase composed of VHL, Elongin B, Elongin C, Cul2 and Rbx1. The VHL protein serves as the substrate recognition component and is linked by Elongin C to a heterodimeric Cul2/Rbx1 module that functions as a potent activator of the ubiquitination of target proteins by an E2 conjugating enzyme. Elongin B interacts with the complex through Elongin C and appears to stabilize the binding of Elongin C to VHL.
Application
Biochem/physiol Actions
Physical form
Other Notes
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