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  • Active food packaging based on molecularly imprinted polymers: study of the release kinetics of ferulic acid.

Active food packaging based on molecularly imprinted polymers: study of the release kinetics of ferulic acid.

Journal of agricultural and food chemistry (2014-11-06)
Pablo Otero-Pazos, Ana Rodríguez-Bernaldo de Quirós, Raquel Sendón, Elena Benito-Peña, Victoria González-Vallejo, M Cruz Moreno-Bondi, Immaculada Angulo, Perfecto Paseiro-Losada
ABSTRACT

A novel active packaging based on molecularly imprinted polymer (MIP) was developed for the controlled release of ferulic acid. The release kinetics of ferulic acid from the active system to food simulants (10, 20, and 50% ethanol (v/v), 3% acetic acid (w/v), and vegetable oil), substitutes (95% ethanol (v/v) and isooctane), and real food samples at different temperatures were studied. The key parameters of the diffusion process were calculated by using a mathematical modeling based on Fick's second law. The ferulic acid release was affected by the temperature as well as the percentage of ethanol of the simulant. The fastest release occurred in 95% ethanol (v/v) at 20 °C. The diffusion coefficients (D) obtained ranged between 1.8 × 10(-11) and 4.2 × 10(-9) cm(2)/s. A very good correlation between experimental and estimated data was obtained, and consequently the model could be used to predict the release of ferulic acid into food simulants and real food samples.

MATERIALS
Product Number
Brand
Product Description

Supelco
5α-Androstan-17β-ol-3-one, VETRANAL®, analytical standard
Sigma-Aldrich
Methanol-12C, 99.95 atom % 12C
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trans-Ferulic acid, ≥99%
Sigma-Aldrich
Methanol solution, NMR reference standard, 4% in methanol-d4 (99.8 atom % D), NMR tube size 3 mm × 8 in.
Supelco
trans-Ferulic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Sigma-Aldrich
Dichlorodimethylsilane, produced by Wacker Chemie AG, Burghausen, Germany, ≥99.0% (GC)
Supelco
trans-Ferulic acid, matrix substance for MALDI-MS, ≥99.0% (HPLC)
Sigma-Aldrich
Dichlorodimethylsilane, ≥98.5% (GC)
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5α-Androstan-17β-ol-3-one, purum, ≥99.0% (TLC)
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trans-Ferulic acid, 99%
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2,2,4-Trimethylpentane, anhydrous, 99.8%
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2-(Dimethylamino)ethyl methacrylate, contains 700-1000 ppm monomethyl ether hydroquinone as inhibitor, 98%
Sigma-Aldrich
Ethyl alcohol, Pure, 190 proof, ACS spectrophotometric grade, 95.0%
Supelco
2,2,4-Trimethylpentane, analytical standard
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5α-Androstan-17β-ol-3-one, ≥97.5%
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Ethanol, BioUltra, for molecular biology, ≥99.8%, (absolute alcohol, without additive, A15 o1)
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Dichlorodimethylsilane, ≥99.5%
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Ethanol, for residue analysis
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Ethanol, tested according to Ph. Eur.
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2,2,4-Trimethylpentane, suitable for HPLC, ≥99%
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2,2,4-Trimethylpentane, ACS reagent, ≥99.0%
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Ethyl alcohol, Pure, 200 proof, ACS reagent, ≥99.5%
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2,2,4-Trimethylpentane, ReagentPlus®, ≥99%
Millipore
Bifido Selective Supplement B, suitable for microbiology
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2,2,4-Trimethylpentane, puriss. p.a., ≥99.5% (GC)
USP
Glacial acetic acid, United States Pharmacopeia (USP) Reference Standard
USP
Methyl alcohol, United States Pharmacopeia (USP) Reference Standard
2-(Dimethylamino)ethyl methacrylate, European Pharmacopoeia (EP) Reference Standard
Ferulic acid, European Pharmacopoeia (EP) Reference Standard
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Ethyl alcohol, Pure, 200 proof, meets USP testing specifications