- Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARalpha/gamma agonists.
Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARalpha/gamma agonists.
The Journal of organic chemistry (2003-03-29)
Alexander G Godfrey, Dawn A Brooks, Lynne A Hay, Mary Peters, James R McCarthy, David Mitchell
PMID12662031
ABSTRACT
An improved method for the preparation of a series of oxazole-containing dual PPARalpha/gamma agonists is described. A synthetic sequence utilizing a Dakin-West reaction was devised that allows for the introduction of the oxazole ring either late in the synthetic sequence via aminomalonate-derived chemistry or in pivotal SAR intermediates derived from aspartic acid.
MATERIALS