- Synthesis and biological evaluation of abietic acid derivatives.
Synthesis and biological evaluation of abietic acid derivatives.
European journal of medicinal chemistry (2009-02-17)
Miguel A González, Julieth Correa-Royero, Lee Agudelo, Ana Mesa, Liliana Betancur-Galvis
PMID19217699
ABSTRACT
A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and antiviral activities. In general, the introduction of an aldehyde group at C18 did improve the resultant bioactivity, while the presence of an acid or alcohol led to less active compounds.
MATERIALS