TFE3
transcription factor binding to IGHM enhancer 3
Synonyms:
RCCP2, RCCX1, TFEA, bHLHe33
Species:
Human TFE3 (7030), Mouse Tfe3 (209446), Rat Tfe3 (317376), naked mole-rat Tfe3 (101715111), domestic guinea pig Tfe3 (100733366), sheep TFE3 (101106403), dog TFE3 (491872), cow TFE3 (520800), domestic cat TFE3 (101099025)
UniProtKB ID:
Gene ID:
- Human(7030) Summary: The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.[provided by RefSeq, Dec 2009]
- Mouse(209446) transcription factor E3
- Rat(317376) transcription factor binding to IGHM enhancer 3
- naked mole-rat(101715111) transcription factor binding to IGHM enhancer 3
- domestic guinea pig(100733366) transcription factor binding to IGHM enhancer 3
- sheep(101106403) transcription factor binding to IGHM enhancer 3
- dog(491872) transcription factor binding to IGHM enhancer 3
- cow(520800) transcription factor binding to IGHM enhancer 3
- domestic cat(101099025) transcription factor binding to IGHM enhancer 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TFE3 (N-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, human, mouse
Application
ELISA
western blot
western blot
Anti-Transcription Factor E3 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-TFE3 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
immunocytochemistry
western blot
western blot
Anti-TFE3 antibody, Mouse monoclonal, clone TFE3-37, purified from hybridoma cell culture,
Species Reactivity
bovine, canine, human, mouse, rat
Application
western blot
Anti-TFE3 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL12822, purified by using Protein A, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
esiRNA
Product Number
Description
Species