MED12
mediator complex subunit 12
Synonyms:
ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230
Species:
Human MED12 (9968), Mouse Med12 (59024), Rat Med12 (679693), Zebrafish med12 (566632), Horse MED12 (100056909), cow MED12 (520974), sheep MED12 (101123015), dog MED12 (480952), domestic cat MED12 (101090673), chicken MED12 (422210) ...More
UniProtKB ID:
Gene ID:
- Human(9968) Summary: The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
- Mouse(59024) mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
- Rat(679693) mediator complex subunit 12
- Zebrafish(566632) mediator of RNA polymerase II transcription, subunit 12 homolog
- Horse(100056909) mediator complex subunit 12
- cow(520974) mediator complex subunit 12
- sheep(101123015) mediator complex subunit 12
- dog(480952) mediator complex subunit 12
- domestic cat(101090673) mediator complex subunit 12
- chicken(422210) mediator complex subunit 12
- domestic guinea pig(100713106) mediator complex subunit 12
- naked mole-rat(101714647) mediator complex subunit 12
- Domestic Rabbit(100350850) mediator complex subunit 12
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MED12 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-MED12 antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot