LIG4
ligase IV, DNA, ATP-dependent
Synonyms:
Species:
Human LIG4 (3981), Mouse Lig4 (319583), Rat Lig4 (290907), fruit fly Lig4 (32322), chicken LIG4 (418764), Zebrafish lig4 (569525), naked mole-rat Lig4 (101722009), cow LIG4 (781252), dog LIG4 (485544), domestic guinea pig Lig4 (100719171) ...More
UniProtKB ID:
Gene ID:
- Human(3981) Summary: The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
- Mouse(319583) ligase IV, DNA, ATP-dependent
- Rat(290907) ligase IV, DNA, ATP-dependent
- fruit fly(32322) Ligase4
- chicken(418764) ligase IV, DNA, ATP-dependent
- Zebrafish(569525) ligase IV, DNA, ATP-dependent
- naked mole-rat(101722009) ligase IV, DNA, ATP-dependent
- cow(781252) ligase IV, DNA, ATP-dependent
- dog(485544) ligase IV, DNA, ATP-dependent
- domestic guinea pig(100719171) ligase IV, DNA, ATP-dependent
- domestic cat(101087961) ligase IV, DNA, ATP-dependent
- Horse(100051479) ligase IV, DNA, ATP-dependent
- sheep(101116239) ligase IV, DNA, ATP-dependent
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-LIG4, (C-terminal) antibody produced in mouse, clone 2D2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-DNL4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-LIG4 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-LIG4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
Anti-LIG4 antibody produced in rabbit, ,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot