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  • Participation of macrophages in chloramphenicol-potentiated carrageenin-induced peritonitis in rats.

Participation of macrophages in chloramphenicol-potentiated carrageenin-induced peritonitis in rats.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (1993-05-01)
J R Moraes, F R Moraes, G H Bechara
ABSTRACT

1. We investigated the possible potentiating effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the response of polymorphonuclear neutrophils to carrageenin (150 micrograms, ip) or dextran (100 micrograms, ip) in the peritoneal cavity of male Wistar rats (180-230 g; N = 12 in each group). 2. Chloramphenicol potentiated the cell migration induced by carrageenin (35%) but not that induced by dextran. Previous macrophage depletion in the peritoneal cavity by washing with sterile saline abolished the cell response, whereas a previous thioglycollate-induced increase in macrophage numbers enhanced the potentiating effect (60%). 3. These results suggest that the potentiating effect on polymorphonuclear neutrophil migration induced by chloramphenicol may be related to chemotactic factors released by macrophages.

MATERIALS
Product Number
Brand
Product Description

Chloramphenicol sodium succinate, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Chloramphenicol succinate sodium salt, ≥80% (HPLC)