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  • Pore expansion of highly monodisperse phenylene-bridged organosilica spheres for chromatographic application.

Pore expansion of highly monodisperse phenylene-bridged organosilica spheres for chromatographic application.

Talanta (2010-03-20)
Yongping Zhang, Yu Jin, Hui Yu, Peichun Dai, Yanxiong Ke, Xinmiao Liang
ABSTRACT

Monodisperse phenylene-bridged organosilica spheres show great potential as chromatographic stationary phase. In this paper, the tunable particle size of monodisperse phenylene-bridged organosilica spheres were prepared by co-condensing different proportion of 1,4-bis(triethoxysilyl)benzene (1,4-BTEB) and tetraethylorthosilicate (TEOS), and then pore size was expanded by two-step post-synthesis hydrothermal treatments using N,N-dimethyldecylamine (DMDA)/dodecylamine (DDA) and tris-(hydroxymethyl)-aminomethane (TRIS) in turn. Phenylene-bridged organosilica spheres with particle size of 3.0-3.5microm and pore size of 85A were further surface modified by C(18) group and tested in reversed-phase high performance liquid chromatography (RP-HPLC). The primary chromatographic results demonstrated that C(18) bonded phenylene-bridged organosilica stationary phase has high retention and good chemical stability in the high pH mobile phase, which indicated that the phenylene-bridged organosilica can be used for HPLC packing supports.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Dodecylamine, puriss., ≥99.5% (GC)
Sigma-Aldrich
Dodecylamine, 98%
Sigma-Aldrich
Dodecylamine, ≥99%
Sigma-Aldrich
N,N-Dimethyldecylamine, 98%