SRP6507
Haptoglobin (Phenotype 1-1) from human plasma
≥95% (SDS-PAGE)
Synonym(s):
Hp 1-1
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
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General description
Haptoglobin is a positive acute-phase plasma α2-sialoglycoprotein, and exists as three major phenotypes namely Hp 1-1, Hp 2-1, and Hp 2-2. Haptoglobin is composed of heavy β- (40 kDa) and light α- (α1= 8.9kDa and α2= 16kDa) chains. Hp 1-1 is the smallest phenotype with a molecular weight of 86kDa, and is composed of only α1.
Biochem/physiol Actions
Haptoglobin functions as an antioxidant by binding free hemoglobin, and eliminates it from circulation to prevent iron loss and renal injury following hemolysis. It is responsible for maintaining the helper T-cell type 1 and type 2 (Th1/Th2) balance, and functions as an immunosuppressor of lymphocyte function. It also functions as an angiogen and anti-inflammatory agent. Hp 1-1 phenotype is most effective in binding free hemoglobin and preventing inflammatory responses linked with free hemoglobin. Studies show that all the three phenotypes of haptoglobin are involved in idiopathic generalized epilepsy.
Physical form
Lyophilized as a salt-free solid.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Haptoglobin phenotypes in epilepsy.
Sadrzadeh SM, et al.
Clinical Chemistry, 50(6), 1095-1097 (2004)
Haptoglobin phenotypes in health and disorders.
Sadrzadeh SM, Bozorgmehr J, et al.
American Journal of Clinical Pathology, 121, S97-104 (2004)
Determination of haptoglobin genotype in an Iranian population with idiopathic generalized epilepsy.
Al-Balaghee S et al
Reports of Biochemistry and Molecular Biology, 3(2), 51-55 (2015)
Fabiana Baganha et al.
International journal of molecular sciences, 23(21) (2022-11-12)
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eLife, 9 (2020-06-10)
Energy-coupling factor type transporters (ECF) represent trace nutrient acquisition systems. Substrate binding components of ECF-transporters are membrane proteins with extraordinary affinity, allowing them to scavenge trace amounts of ligand. A number of molecules have been described as substrates of ECF-transporters
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