N8028

Nikkomycin Z from Streptomyces tendae

≥90% (HPLC)

• Synonym(s): Neopolyoxin C, Nikkomycin Z
• Empirical Formula (Hill Notation): C₂₀H₂₅N₅O₁₀
• CAS Number: 59456-70-1
• Molecular Weight: 495.44
• MDL number: MFCD00869648
• UNSPSC Code: 51102829
• PubChem Substance ID: 24897849
• NACRES: NA.85

Properties

• Quality Level: 200
• Assay: ≥90% (HPLC)
• form: powder
• solubility: H₂O: soluble 5 mg/mL
• antibiotic activity spectrum: fungi
• Mode of action: cell wall synthesis | interferes; enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: C[C@@H]([C@H](N)C(=O)N[C@H]([C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O)C(O)=O)[C@H](O)c3ccc(O)cn3
• InChI: 1S/C20H25N5O10/c1-7(13(28)9-3-2-8(26)6-22-9)11(21)17(31)24-12(19(32)33)16-14(29)15(30)18(35-16)25-5-4-10(27)23-20(25)34/h2-7,11-16,18,26,28-30H,21H2,1H3,(H,24,31)(H,32,33)(H,23,27,34)/t7-,11-,12+,13-,14-,15+,16+,18+/m0/s1
• InChI key: WWJFFVUVFNBJTN-JKEIIPFCSA-N

Description

General description

Chemical structure: peptidyl nucleoside

Application

Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure.

Biochem/physiol Actions

Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves