ED4S

Ethylenediaminetetraacetic acid tetrasodium salt hydrate

practical grade, ≥95%

• Synonym(s): EDTA tetrasodium salt, Edathamil, Tetrasodium ethylenediaminetetraacetate hydrate
• Linear Formula: (NaOOCCH₂)₂NCH₂CH₂N(CH₂COONa)₂ · xH₂O
• CAS Number: 194491-31-1
• Molecular Weight: 380.17 (anhydrous basis)
• Beilstein: 3861753
• EC Number: 200-573-9
• MDL number: MFCD00150025
• UNSPSC Code: 12352202
• PubChem Substance ID: 24894710
• NACRES: NA.77

Properties

• grade: practical grade
• Assay: ≥95%
• form: powder
• reaction suitability: reagent type: chelator
• solubility: soluble, clear, colorless (32g plus 200ml of water)
• SMILES string: O.[Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O
• InChI: 1S/C10H16N2O8.4Na.H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;;;1H2/q;4*+1;/p-4
• InChI key: GXFFSKMBMYHTAE-UHFFFAOYSA-J

Description

Application

EDTA is an inhibitor of metalloproteases, at effective concentrations of 1-10 mM. EDTA acts as a chelator of the zinc ion in the active site of metalloproteases, and can also inhibit other metal ion-dependent proteases such as calcium-dependent cysteine proteases. For use as an anticoagulant, disodium or tripotassium salts of EDTA are most commonly used. The optimal concentration is 1.5 mg per ml of blood.

Preparation Note

Soluble in water at room temperature up to 1.45 M. The pH of this solution will be approximately 10 to 11 and will be rather viscous.

Safety Information

• Pictograms: GHS08,GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302 + H332,H318,H373
• Precautionary Statements: P280 - P301 + P312 + P330 - P304 + P340 + P312 - P305 + P351 + P338 + P310 - P314
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2
• Target Organs: Respiratory Tract
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves