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T2100000

Trimethadione

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

3,5,5,-Trimethyloxazolidine-2,4-dione, Trimethadione

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About This Item

Empirical Formula (Hill Notation):
C6H9NO3
CAS Number:
127-48-0
Molecular Weight:
143.14
MDL number:
MFCD00047084
UNSPSC Code:
41116107
PubChem Substance ID:
329826702
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

trimethadione

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CN1C(=O)OC(C)(C)C1=O

InChI

1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3

InChI key

IRYJRGCIQBGHIV-UHFFFAOYSA-N

Gene Information

human ... CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Trimethadione EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H312 + H332,H360

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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[Fetal trimethadione syndrome].
T Nagai
Ryoikibetsu shokogun shirizu, (33)(33), 704-704 (2001-07-21)
E Tanaka et al.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 104(2), 205-207 (1993-02-01)
1. Trimethadione (TMO) has the properties required of probe drugs for the evaluation of hepatic oxidizing capacity in vivo. 2. TMO is demethylated to dimethadione (DMO), its only metabolite, in the liver after oral administration. 3. In rats with various
[Fetal trimethadione effects].
Y Nakane
Ryoikibetsu shokogun shirizu, (30 Pt 5)(30 Pt 5), 94-95 (2000-11-01)
E Tanaka et al.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 115(3), 211-216 (1996-11-01)
Trimethadione (TMO) has the properties required of probe drugs for the evaluation of hepatic drug-oxidizing capacity in humans in vivo. TMO is demethylated to dimethadione (DMO), its only metabolite, in the liver after oral administration. Involvement of two cytochrome P450's--CYP2C9

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