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A-917

Supelco

7-Aminoclonazepam-d4 solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C15D4H8ClN3O
CAS Number:
Molecular Weight:
289.75
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland)

concentration

100 μg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

SMILES string

O=C1NC2=CC=C(N)C=C2C(C3=C([2H])C([2H])=C([2H])C([2H])=C3Cl)=NC1

InChI

1S/C15H12ClN3O/c16-12-4-2-1-3-10(12)15-11-7-9(17)5-6-13(11)19-14(20)8-18-15/h1-7H,8,17H2,(H,19,20)/i1D,2D,3D,4D

InChI key

HEFRPWRJTGLSSV-RHQRLBAQSA-N

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General description

An internal standard suitable for use in LC/MS or GC/MS testing methods of 7-aminoclonazepam for clinical toxicology, pain prescription monitoring, forensic analysis, or isotope dilution methods. 7-Aminoclonazepam is a major metabolite of clonazepam, a potent, long-acting benzodiazepine marketed as Klonopin® in the US and Rivotril in many other countries.

Application


  • Matrix Effects in Forensic Toxicology: 7-Aminoclonazepam-d₄ serves as an internal standard in studying matrix effects in forensic toxicology, enhancing the analysis of hyperlipidemic postmortem blood. This research supports the importance of precise quantification of drugs in complex biological matrices (Elenstål et al., 2023).

  • Benzodiazepine Analysis in Various Matrices: The compound is used as an internal standard in comparative studies of postmortem concentrations of benzodiazepines across different biological matrices. This facilitates a broader understanding of drug distribution and postmortem redistribution phenomena (Øiestad et al., 2023).

  • Stability Studies in Analytical Chemistry: Employed in the corrigendum addressing the stability of 7-aminoclonazepam under frozen storage conditions, 7-Aminoclonazepam-d₄ is critical for ensuring the reliability of long-term substance stability studies, highlighting its utility in clinical mass spectrometry (Dahlin and Petrides, 2022).

  • Drug Detection in Oral Fluid: This internal standard is essential for the rapid extraction and qualitative screening of drugs in oral fluid, particularly in driving under the influence of drugs (DUID) cases, demonstrating its role in law enforcement and forensic applications (Coulter et al., 2022).

  • Comparison of Screening Methods: 7-Aminoclonazepam-d₄ is utilized in evaluating the efficacy of immunoassay screening methods versus LC-MS/MS for detecting traditional and designer benzodiazepines in urine, contributing to advancements in toxicological analysis (Rossi et al., 2021).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Klonopin is a registered trademark of Hoffmann-La Roche Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2.0 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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