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  • Redox active molecules cytochrome c and vitamin C enhance heme-enzyme peroxidations by serving as non-specific agents for redox relay.

Redox active molecules cytochrome c and vitamin C enhance heme-enzyme peroxidations by serving as non-specific agents for redox relay.

Biochemical and biophysical research communications (2012-02-22)
Sudeep Kumar Gade, Subarna Bhattacharya, Kelath Murali Manoj
ABSTRACT

We report that incorporation of very low concentrations of redox protein cytochrome c and redox active small molecule vitamin C impacted the outcome of one-electron oxidations mediated by structurally distinct plant/fungal heme peroxidases. Evidence suggests that cytochrome c and vitamin C function as a redox relay for diffusible reduced oxygen species in the reaction system, without invoking specific or affinity-based molecular interactions for electron transfers. The findings provide novel perspectives to understanding - (1) the promiscuous role of cytochrome b(5) in the metabolism mediated by liver microsomal xenobiotic metabolizing systems and (2) the roles of antioxidant molecules in affording relief from oxidative stress.

MATERIALS
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Product Description

Sigma-Aldrich
Chloroperoxidase from Caldariomyces fumago, buffered aqueous suspension, 1,000-2,000 units/mg protein (E1%/280)
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SKUVendor SKUPack SizeAvailabilityPrice
YF-7445-1G1 g
Ships in 14 days - from Aldrich Partner.
€544.58
YF-7445-5G5 g
Ships in 14 days - from Aldrich Partner.
€1,721.40

To order products, please contact your local dealer.

Sigma-Aldrich
Chloroperoxidase from Caldariomyces fumago, buffered aqueous suspension, ≥3,000 units/mL
Sign Into View Organizational & Contract Pricing
SKUVendor SKUPack SizeAvailabilityPrice
YF-7445-1G1 g
Ships in 14 days - from Aldrich Partner.
€544.58
YF-7445-5G5 g
Ships in 14 days - from Aldrich Partner.
€1,721.40

To order products, please contact your local dealer.

Sigma-Aldrich
Chloroperoxidase from Caldariomyces fumago, aqueous suspension, brown, >10,000 U/mL
Sign Into View Organizational & Contract Pricing
SKUVendor SKUPack SizeAvailabilityPrice
YF-7445-1G1 g
Ships in 14 days - from Aldrich Partner.
€544.58
YF-7445-5G5 g
Ships in 14 days - from Aldrich Partner.
€1,721.40

To order products, please contact your local dealer.