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  • Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant.

Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant.

Bioorganic & medicinal chemistry (2010-10-05)
Jun Lu, Omar M Khdour, Jeffrey S Armstrong, Sidney M Hecht
ABSTRACT

An efficient synthesis has provided access to a novel α-tocopherol analogue (2), as well as its trifluoroacetate salt and acetate ester. An annulation reaction was used to establish the pyridinol core structure and a Stille coupling reaction was employed for conjugation with the tocopherol side chain. This analogue was shown to suppress the levels of reactive oxygen species in cultured cells, and to quench peroxidation of mitochondrial membranes.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Abz-SDK(Dnp)P-OH trifluoroacetate salt, ≥91% (HPLC), lyophilized powder
Pricing and availability is not currently available.
Sigma-Aldrich
(+)-α-Tocopherol, Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g
Pricing and availability is not currently available.
Sigma-Aldrich
(+)-α-Tocopherol, from vegetable oil, Type V, ~1000 IU/g
Pricing and availability is not currently available.