Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

SML3164

Sigma-Aldrich

CAM833

≥98% (HPLC)

Synonym(s):

CAM833A, N-(2-((2S,4R)-2-(((S)-1-(2-chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-hydroxypyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C26H26ClFN4O5
Molecular Weight:
528.96
UNSPSC Code:
12352107
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC1=CC=C(N=C(C(NCC(N2[C@H](C(N[C@H](C3=C(Cl)C=C(OC)C=C3)C)=O)C[C@@H](O)C2)=O)=O)C=C4)C4=C1

Biochem/physiol Actions

CAM833 is a potent and selective inhibitor of RAD51:BRCA2 interaction that inhibits RAD51 foci formation in A549 non-small cell lung carcinoma (NSCLC) cells. CAM833 suppresses extended RAD51 filament assembly. It potentiates the DNA damage by ionizing radiation in cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Duncan E Scott et al.
Cell chemical biology, 28(6), 835-847 (2021-03-05)
BRCA2 controls RAD51 recombinase during homologous DNA recombination (HDR) through eight evolutionarily conserved BRC repeats, which individually engage RAD51 via the motif Phe-x-x-Ala. Using structure-guided molecular design, templated on a monomeric thermostable chimera between human RAD51 and archaeal RadA, we
Duncan E Scott et al.
Cell chemical biology, 28(6), 835-847 (2021-03-05)
BRCA2 controls RAD51 recombinase during homologous DNA recombination (HDR) through eight evolutionarily conserved BRC repeats, which individually engage RAD51 via the motif Phe-x-x-Ala. Using structure-guided molecular design, templated on a monomeric thermostable chimera between human RAD51 and archaeal RadA, we

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service