SML0428

GSK690693

≥98% (HPLC)

• Synonym(s): 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol
• Empirical Formula (Hill Notation): C₂₁H₂₇N₇O₃
• CAS Number: 937174-76-0
• Molecular Weight: 425.48
• NACRES: NA.77
• PubChem Substance ID: 329825423
• UNSPSC Code: 12352200
• MDL number: MFCD14105605
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c4nonc4N
• InChI: 1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1
• InChI key: KGPGFQWBCSZGEL-ZDUSSCGKSA-N
• Gene Information: human ... AKT1(207), AKT2(208), AKT3(10000), PRKACA(5566), PRKACB(5567), PRKACG(5568), PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584), PRKCQ(5588), PRKCZ(5590), PRKD1(5587), PRKD3(23683)

Description

Application

GSK690693 has been used in western blotting and immunoprecipitations.

Biochem/physiol Actions

GSK690693 is a potent pan-AKT kinase inhibitor.

GSK690693 is an ATP competitive, potent pan-AKT kinase inhibitor with IC₅₀ values of 2, 13, and 9 nM against AKT1, 2, and 3, respectively.

4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol/GSK690693 is a protein kinase B/AKT inhibitor. GSK690693 can prevent growth and apoptosis in acute lymphoblastic leukemia cell lines.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable