SML0042

Lazabemide hydrate

≥97% (HPLC)

• Synonym(s): N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrate, Ro 19-6327 hydrate
• Empirical Formula (Hill Notation): C₈H₁₀ClN₃O · xH₂O
• CAS Number: 103878-84-8
• Molecular Weight: 199.64 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329825112
• UNSPSC Code: 12352200
• MDL number: MFCD20488051
• Assay: ≥97% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥22 mg/mL
• originator: Roche
• storage temp.: room temp
• SMILES string: O.NCCNC(=O)c1ccc(Cl)cn1
• InChI: 1S/C8H10ClN3O.H2O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10;/h1-2,5H,3-4,10H2,(H,11,13);1H2
• InChI key: JYWYNPKXSLPWGV-UHFFFAOYSA-N

Description

Application

Lazabemide hydrate may be used in cell signaling studies.

Biochem/physiol Actions

Lazabemide is a selective and reversible monoamine oxidase B (MAO-B) inhibitor and Anti-Parkinson. Also it inhibits monoamine uptake at high concentrations (IC₅₀ values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively).

Lazabemide is effective in treatment of Alzheimer′s disease and in combination with nicotine replacement therapy aids in smoking cessation.

Selective MAO-B inhibitor; Antiparkinson

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319
• pcodes: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable