P2076

Polymyxin B nonapeptide hydrochloride

lyopholized powder

• Synonym(s): PMBN
• Empirical Formula (Hill Notation): C₄₃H₇₄N₁₄O₁₁ · xHCl
• Molecular Weight: 963.13 (free base basis)
• UNSPSC Code: 12352209
• PubChem Substance ID: 24898270
• NACRES: NA.26
• MDL number: MFCD00214217

Properties

• Product Name: Polymyxin B nonapeptide hydrochloride, cationic cyclic peptide
• Quality Segment: 200
• form: lyophilized powder
• color: white to light yellow
• application(s): cell analysis
• storage temp.: 2-8°C
• SMILES string: CC(C)CC1NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC(=O)C(CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC1=O)C(C)O)NC(=O)C(CCN)NC(=O)C(N)C(C)O
• InChI: 1S/C43H74N14O11/c1-22(2)20-31-40(65)52-26(10-15-44)35(60)51-29(13-18-47)39(64)57-34(24(4)59)43(68)49-19-14-30(53-36(61)28(12-17-46)54-42(67)33(48)23(3)58)38(63)50-27(11-16-45)37(62)56-32(41(66)55-31)21-25-8-6-5-7-9-25/h5-9,22-24,26-34,58-59H,10-21,44-48H2,1-4H3,(H,49,68)(H,50,63)(H,51,60)(H,52,65)(H,53,61)(H,54,67)(H,55,66)(H,56,62)(H,57,64)
• InChI key: PYHYGIPVYYRJHU-UHFFFAOYSA-N

Description

Application

Polymyxin B nonapeptide hydrochloride has been used as an outer membrane permeabilizer, to characterize PAβN activity on membrane. It has been used as a control in antibacterial assays.

Biochem/physiol Actions

PMBN has endotoxin-neutralizing activity and thus can be utilized in adjunctive therapy against Gram-negative sepsis. It has been found that PMBN is less toxic than polymyxin B. Unlike polymyxin B, PMBN does not exhibit neurotoxicity and nephrotoxicity. While it retains the anti endotoxin property of the parent compound, it is much less potent.

Polymyxin B nonapeptide (PMBN), a cationic cyclic peptide derived from the antibacterial peptide polymyxin B, specifically increases the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics.[1][2][3] PMBN has been used to evaluate multidrug efflux inhibitors in E. coli.[4]

Polymyxin B nonapeptide hydrochloride is a derivative of PMB that induces outer membrane permeability in gram-negative bacteria.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)