P0022

PS48

≥98% (HPLC)

• Synonym(s): 5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid
• Empirical Formula (Hill Notation): C₁₇H₁₅ClO₂
• CAS Number: 1180676-32-7
• Molecular Weight: 286.75
• MDL number: MFCD17215962
• UNSPSC Code: 12352200
• PubChem Substance ID: 329819977
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(=O)\C=C(\CCc1ccc(Cl)cc1)c2ccccc2
• InChI: 1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
• InChI key: LLJYFDRQFPQGNY-QINSGFPZSA-N

Description

Biochem/physiol Actions

PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable