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N3538

Nateglinide

≥98% (HPLC), solid

Synonym(s):

Fastic, N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanine, Starlix, Starsis

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10 mg

Available to ship TODAYfromMILWAUKEE

$290.00
$246.50

About This Item

Empirical Formula (Hill Notation):
C19H27NO3
CAS Number:
105816-04-4
Molecular Weight:
317.42
NACRES:
NA.77
PubChem Substance ID:
329818636
UNSPSC Code:
12352200
MDL number:
MFCD00875706
Assay:
≥98% (HPLC)
Form:
solid

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assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: >5 mg/mL, H2O: insoluble

originator

Novartis

storage temp.

room temp

SMILES string

CC(C)[C@@H]1CC[C@H](CC1)C(=O)N[C@H](Cc2ccccc2)C(O)=O

InChI

1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-,17-/m1/s1

InChI key

OELFLUMRDSZNSF-BRWVUGGUSA-N

Gene Information

human ... ABCC8(6833), KCNJ11(3767)

Biochem/physiol Actions

Nateglinide is a Kir6.2/SUR1 channel inhibitor and antidiabetic.
Nateglinide is a Kir6.2/SUR1 channel inhibitor and antidiabetic. It is selective for the SUR1 subtype, which is found on pancreatic islet cells. Nateglinide evokes KATP channel-dependent insulin secretion (50-200 μM) in the absence and presence of insulin.
Nateglinide is a short-acting insulin secretagogue useful in treating type 2 diabetes.[1] It is an insulinotropic agent effective for postprandial hyperglycemia. Nateglinide restores prandial insulin levels in a glucose-dependent manner.[2]

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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1 of 1

This Item
1457607Y0001437J3770
Nateglinide ≥98% (HPLC), solid

Sigma-Aldrich

N3538

Nateglinide

Nateglinide United States Pharmacopeia (USP) Reference Standard

USP

1457607

Nateglinide

Nateglinide European Pharmacopoeia (EP) Reference Standard

Y0001437

Nateglinide

JNJ7777120 ≥98% (HPLC)

Sigma-Aldrich

J3770

JNJ7777120

assay

≥98% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

form

solid

form

-

form

-

form

solid

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

room temp

storage temp.

-

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: >5 mg/mL, H2O: insoluble

solubility

-

solubility

-

solubility

DMSO: >20 mg/mL, H2O: insoluble

color

white to off-white

color

-

color

-

color

white to off-white

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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