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A165

Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt

≥98% (HPLC), cAMP antagonist, powder

Synonym(s):

Rp-Cyclic 3′,5′-hydrogen phosphorothioate adenosine triethylammonium salt, Rp-cAMPS triethylammonium salt

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1 mg

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$208.00
5 mg
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$862.00
10 mg

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$1,620.00

About This Item

Empirical Formula (Hill Notation):
C10H11N5O5PS · C6H16N
CAS Number:
151837-09-1
Molecular Weight:
446.46
UNSPSC Code:
41106305
PubChem Substance ID:
24890575
NACRES:
NA.77
MDL number:
MFCD03703495
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

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Product Name

Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt, powder, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL

λmax

258 nm

storage temp.

−20°C

SMILES string

CCN(CC)CC.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=S)O[C@H]4[C@H]3O

InChI

1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21?;/m1./s1

InChI key

OXIPZMKSNMRTIV-NVGWRVNNSA-N

Application

Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt has been used as an antagonist of cAMP to block the cAMP-PKA signal pathway.

Biochem/physiol Actions

Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt is capable of inhibiting protein kinase A (PKA).
Rp-Diastereomer of adenosine-3′,5′-cyclic monophosphothioate. Specific membrane-permeable inhibitor of activation by cAMP of cAMP-dependent protein kinase I and II; resistant toward cyclic nucleotide phosphodiesterases; blocks cAMP-mediated effects in numerous systems.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Disclaimer

Extremely hygroscopic. Store desiccated.

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This Item
A166B6684A6885
Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt powder, ≥98% (HPLC)

Sigma-Aldrich

A165

Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt

Sp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt hydrate ≥98% (HPLC), solid

Sigma-Aldrich

A166

Sp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt hydrate

Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt ≥98% (HPLC), powder

Sigma-Aldrich

B6684

Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt

Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate ≥98.0% (HPLC), powder

Sigma-Aldrich

A6885

Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98.0% (HPLC)

form

powder

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

H2O: 10 mg/mL

solubility

H2O: soluble

solubility

H2O: 15 mg/mL at ≤60 °C

solubility

H2O: 10 mg/mL

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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