85610

Spermine tetrahydrochloride

From microbial,synthetic, ≥99.0% (AT), NMDA agonist/antagonist, powder or crystals

• Synonym(s): N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
• Empirical Formula (Hill Notation): C₁₀H₂₆N₄ · 4HCl
• CAS Number: 306-67-2
• Molecular Weight: 348.18
• NACRES: NA.77
• PubChem Substance ID: 329769394
• UNSPSC Code: 12352200
• EC Number: 206-189-8
• MDL number: MFCD00012914
• Beilstein/REAXYS Number: 3911771
• Assay: ≥99.0% (AT)
• Form: powder or crystals

Properties

• Product Name: Spermine tetrahydrochloride, ≥99.0% (AT), powder or crystals
• Quality Segment: 300
• biological source: microbial, synthetic
• assay: ≥99.0% (AT)
• form: powder or crystals
• mp: 310-311 °C (dec.) (lit.)
• solubility: H₂O: 0.1 g/mL, clear
• storage temp.: room temp
• SMILES string: Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
• InChI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• InChI key: XLDKUDAXZWHPFH-UHFFFAOYSA-N

Description

Application

Used to precipitate DNA from low salt aqueous buffers.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves