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Merck

313M-1

Cytokeratin Cocktail (AE1 & AE3) Mouse Monoclonal Antibody

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
AE1 & AE3, monoclonal
Application:
IHC (p)
Citations:
4

Key Documents

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biological source

mouse

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

AE1 & AE3, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (313M-14), vial of 0.5 mL concentrate (313M-15), bottle of 1.0 mL predilute (313M-17), vial of 1.0 mL concentrate (313M-16), bottle of 7.0 mL predilute (313M-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1κ

control

breast, colon, prostate, skin

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KRT1(3848)

Related Categories

General description

Anti-cytokeratin cocktail (AE1 & AE3) is a broad-spectrum keratin antibody cocktail. It is composed of mouse monoclonal antibody AE1 that recognizes acidic type I keratins and AE3 that reacts with basic type II keratins. Both clones were generated using epidermal keratin as immunogen. This antibody is useful for identifying cells of epithelial origin and detects most carcinomas of different primarysites. This antibody cocktail can cross-react with other intermediate filaments, such as glialfibrillary acidic protein, giving false-positive staining in glial tumors.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note


IVD
IVD
IVD
RUO

Other Notes

Cytokeratin Cocktail Positive Control Slides, Product No. 313S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

Lot/Batch Number
0000526566
0000474575
0000474578
0000474575
0000474578

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V K Kriho et al.
Virchows Archiv : an international journal of pathology, 431(2), 139-147 (1997-08-01)
Several studies have shown that immunoenzymatic staining of formalin-fixed, paraffin-embedded astrocytomas with keratin antibodies frequently yields positive labelling, but no biochemical evidence of keratin expression in astrocytomas has been reported. We have investigated the presence of keratin in astrocytoma and
Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations.
D Cooper et al.
Laboratory investigation; a journal of technical methods and pathology, 52(3), 243-256 (1985-03-01)
A M Gown et al.
American journal of clinical pathology, 84(4), 413-424 (1985-10-01)
A panel of monoclonal antibodies to human intermediate filament proteins was tested on an unselected series of 246 neoplasms. The antibody panel includes two different anti-cytokeratin antibodies, an anti-vimentin antibody, and an anti-neurofilament antibody (Gown and Vogel, Am J Pathol
H Battifora
The American journal of surgical pathology, 12 Suppl 1, 24-42 (1988-01-01)
The past few years have seen great progress in our knowledge of the biology and the chemistry of intermediate filaments and other filamentous proteins. This has translated into the development of antibodies that, together with new, highly sensitive immunohistochemical methods

Global Trade Item Number

SKUGTIN
313M-160841683135142
313M-12-VENT04061838384829
313M-180841683135166
313M-140841683135128
313M-150841683135135
313M-170841683135159

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