23-055-M
Cardiac Troponin I, 10 µg
Full length, recombinant human Cardiac Troponin I. N-terminal c-Myc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.
Synonym(s):
Troponin I, cardiac muscle, TNNI3, TNNC1
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| Size/SKU | Availability | Price |
|---|---|---|
10 μg | Check Cart for Availability | $730.00 |
About This Item
UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
$730.00
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General description
Troponin is a complex of three regulatory proteins (Troponin I, Troponin T and Troponin C). It is located on the actin filament and is essential for the calcium-mediated regulation of skeletal and cardiac muscle contraction. There are tissue-specific isoforms of Troponin I, T and C and two subtypes (Cardiac Troponin I and T) are released when the heart muscle has been damaged, such as during a heart attack. The more damage there is to the heart, the greater the amount of Troponin I and T there will be in the blood and currently, Cardiac Troponin I and T are used as the preferred biochemical markers for the diagnosis of myocardial infarction. It has also been demonstrated that Cardiac Troponin I is targeted for degradation by MuRF1, an E3 ubiquitin ligase that has been linked to muscle atrophy
Application
Ubiquitination Cascade Comoponent: Substrate
Physical form
Purified using immobilized metal affinity chromatography.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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This Item | |||
|---|---|---|---|
| technique(s) activity assay: suitable | technique(s) - | technique(s) western blot: suitable | technique(s) - |
| recombinant expressed in baculovirus infected Sf21 cells | recombinant - | recombinant - | recombinant expressed in E. coli |
| biological source human | biological source - | biological source mouse | biological source human |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level - |
| NCBI accession no. | NCBI accession no. - | NCBI accession no. | NCBI accession no. |
| manufacturer/tradename Upstate® | manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename - |
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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