219372

Cathepsin G Inhibitor I

≥98% (HPLC), solid, cathepsin G inhibitor, Calbiochem^®

• Synonym(s): Cathepsin G Inhibitor I
• Empirical Formula (Hill Notation): C₃₆H₃₃N₂O₆P
• CAS Number: 429676-93-7
• Molecular Weight: 620.63
• MDL number: MFCD28137715
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Properties

• Product Name: Cathepsin G Inhibitor I, The Cathepsin G Inhibitor I, also referenced under CAS 429676-93-7, controls the biological activity of Cathepsin G. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• potency: 53 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 5 mg/mL, methanol: soluble
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [P](=O)(O)(O)C(c5c6c(ccc5)cccc6)C(=O)c1cc2c(cc1C(=O)N(C3CCN(CC3)C(=O)c4ccccc4)C)cccc2
• InChI: 1S/C36H33N2O6P/c1-37(28-18-20-38(21-19-28)35(40)25-11-3-2-4-12-25)36(41)32-23-27-14-6-5-13-26(27)22-31(32)33(39)34(45(42,43)44)30-17-9-15-24-10-7-8-16-29(24)30/h2-17,22-23,28,34H,18-21H2,1H3,(H2,42,43,44)
• InChI key: GNOZQRKYZJSIPZ-UHFFFAOYSA-N

Description

General description

A potent, selective, reversible, and competitive non-peptide inhibitor of cathepsin G (IC₅₀ = 53 nM and K_i = 63 nM). Weakly inhibits chymotrypsin (K_i = 1.5 µM) and does not have any significant inhibitory effect on thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC₅₀ >100 µM).

A potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G [IC₅₀ = 53 nM and K_i = 63 nM]. Weakly inhibits chymotrypsin (K_i = 1.5 µM) and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC₅₀ >100 µM).

Biochem/physiol Actions

Target K_i: 63 nM for cathepsin G

Product does not compete with ATP.

Reversible: yes

Primary Target
cathepsin G

Cell permeable: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Greco, M.N., et al. 2002. J. Am. Chem. Soc.124, 3810.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable