1458009

Neomycin sulfate

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): Neomycin trisulfate salt, Neomycin B sulfate
• Empirical Formula (Hill Notation): C₂₃H₄₆N₆O₁₃ · 3H₂SO₄
• CAS Number: 1405-10-3
• Molecular Weight: 908.88
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: neomycin
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• InChI: 1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22?,23+;/m1./s1
• InChI key: OIXVKQDWLFHVGR-GQTDVWSESA-N

Description

General description

Neomycin Sulfate is the sulfate salt of a kind of neomycin, an antibacterial substance produced by the growth of Streptomyces fradiae Waksman (Fam. Streptomycetaceae), or a mixture of two or more such salts, the main component being neomycin B sulfate. It has a potency equivalent to NLT 600 µg of neomycin/mg, calculated on the dried basis.
Neomycin sulfate USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Neomycin sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Neomycin Sulfate Tablets
• Neomycin Sulfate Cream
• Neomycin Sulfate Ointment
• Neomycin Sulfate Ophthalmic Ointment
• Neomycin Sulfate Oral Solution
• Neomycin Sulfate and Hydrocortisone Cream

Caution

Stock solutions should be filter sterilized and stored at 2-8°C, and are stable at 37°C for 5 days. A 1 mg/mL neomycin solution in .1 M phosphate buffer, pH 8.0 should be used within 14 days when stored at 0-5°C. Solutions should be protected from light or moisture.

Preparation Note

Neomycin sulfate is soluble in H₂O at 50 mg/mL, yielding a clear solution.

Other Notes

This product is part of the USP Biologics program.

Legal Information

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H317,H334
• Precautionary Statements: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable