SML2514

Nedaplatin

• Synonym(s): Nedaplatin, Cis-Diammine (Glycolato)Platinum
• Empirical Formula (Hill Notation): C₂H₈N₂O₃Pt
• CAS Number: 95734-82-0
• Molecular Weight: 303.17
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• form: powder
• storage temp.: 2-8°C
• InChI: 1S/C2H4O3.2H2N.Pt/c3-1-2(4)5;;;/h3H,1H2,(H,4,5);2*1H2;/q;2*-1;+2
• InChI key: KLNFSAOEKUDMFA-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Nedaplatin is a second-generation cisplatin analog with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. Nedplatin is less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H300,H315,H317,H319,H334,H335,H350
• Precautionary Statements: P202 - P261 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1B - Skin Irrit. 2 - Skin Sens. 1B - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable