Skip to Content
Merck
All Photos(3)

Documents

F8791

Sigma-Aldrich

5-Fluoro-5′-deoxyuridine

Synonym(s):

Doxifluridine, 5′dFUrd

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C9H11FN2O5
CAS Number:
3094-09-5
Molecular Weight:
246.19
EC Number:
221-440-1
MDL number:
MFCD00866530
UNSPSC Code:
12352200
PubChem Substance ID:
24278444
NACRES:
NA.77

Quality Level

200

SMILES string

C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(F)C(=O)NC2=O

InChI

1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1

InChI key

ZWAOHEXOSAUJHY-ZIYNGMLESA-N

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Hitoshi Miyakoshi et al.
Journal of medicinal chemistry, 55(7), 2960-2969 (2012-03-13)
Recently, deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug development as part of a new strategy of 5-fluorouracil-based combination chemotherapy. We have initiated a program to develop potent drug-like dUTPase inhibitors based on structure-activity relationship (SAR) studies
Dengke Pan et al.
Chemical communications (Cambridge, England), 47(3), 908-910 (2010-11-17)
Nearly monodispersed magnetic Fe(3)O(4)@DFUR-LDH submicro particles containing the anticancer agent DFUR were prepared via a coprecipitation-calcination-reconstruction strategy of LDH materials over the surface of Fe(3)O(4) particles, and present well-defined core-shell structure, strong magnetization and obvious magnetically controlled drug delivery and
Y Tanaka et al.
Cancer research, 50(15), 4528-4532 (1990-08-01)
Murine colon 26 adenocarcinoma causes a progressive weight loss and physiological changes associated with cachexia when it grows to a certain size. By the use of this tumor model several types of cytostatics were examined for their ability to alleviate
G J Peters et al.
International journal of cancer, 54(3), 450-455 (1993-05-28)
Malignant activation of oncogenes ras or trk is implicated in a number of solid tumors and leukemias. We determined the chemosensitivity profile of wild-type mouse NIH-3T3 fibroblasts, and that of NIH-3T3 lines transformed by the H-ras (S2-721) and trk (106-632)
Linda Connelly et al.
Breast cancer research : BCR, 13(4), R83-R83 (2011-09-03)
Metastasis from primary tumor to the lungs is a major cause of the mortality associated with breast cancer. Both immune and inflammatory responses impact whether circulating mammary tumor cells successfully colonize the lungs leading to established metastases. Nuclear factor -kappaB
View All Related Papers

Articles

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service