C1617

C Reactive Protein human

recombinant, expressed in E. coli, liquid

• Synonym(s): CRP
• MDL number: MFCD00130690
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• recombinant: expressed in E. coli
• form: liquid
• mol wt: 23 kDa
• bp: ~100 °C
• UniProt accession no.: P02741
• storage temp.: 2-8°C
• Gene Information: human ... CRP(1401)

Description

General description

C-reactive protein (CRP), a homopentameric acute-phase inflammatory protein, is produced mainly in liver hepatocytes. This highly conserved plasma protein is also produced by smooth muscle cells, macrophages, endothelial cells, lymphocytes, and adipocytes. It belongs to the pentraxin family.

Application

C Reactive Protein human has been used:

• as a component in differentiation medium to study the effects of C-reactive protein (CRP) on the size of myotubes and myotube mixed protein synthesis (MPS)
• to study the influence of serum CRP level from elderly on endothelial cell proliferation in human umbilical vein endothelial cells (HUVEC)
• to study the roles and connections of nicotine, monocytic interleukin 6 (IL-6), α7 nicotinic acetylcholine receptor (α7-nAChR), and CRP in the development of coronary artery spasm (CAS)

Biochem/physiol Actions

C-reactive protein (CRP) plays a key role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of interleukin-6 and tumor necrosis factor-α. It participates in the uptake of low-density lipoprotein in macrophages. CRP levels are elevated in people suffering from appendicitis, cholecystitis, pancreatitis, and meningitis. It plays a vital role in the pathophysiology of cardiovascular disease. Hence it is used as a marker of infection and cardiovascular events.

C-reactive protein (CRP) is a protein that could precipitate the C-polysaccharide of pneumococcal cell walls. CRP is widely used as a clinical marker of the state of inflammation, since its production by hepatocytes increases during the acute phase of the inflammatory response.

Analysis Note

A highly purified protein and made by a fermentation process using genetically modified E. coli.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable