RMNPMAG-83K
MILLIPLEX® Rat/Mouse Neuropeptide Magnetic Bead Panel - Neuroscience Multiplex Assay
The analytes available for this multiplex kit are: α-MSH, β-Endorphin, Neurotensin, Oxytocin, Substance P.
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About This Item
UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84
Recommended Products
Quality Level
species reactivity
mouse, rat
manufacturer/tradename
Milliplex®
assay range
accuracy: 107-135%
(Rat)
standard curve range: 14-100,000 pg/mL
(Oxytocin)
standard curve range: 27-20,000 pg/mL
(Neurotensin)
standard curve range: 3-2,000 pg/mL
(Substance P)
standard curve range: 41-30,000 pg/mL
(α-MSH)
standard curve range: 69-50,000 pg/mL
(β-Endorphine)
technique(s)
multiplexing: suitable
detection method
fluorometric (Luminex xMAP)
shipped in
wet ice
General description
The MILLIPLEX® Rat/Mouse Neuropeptide Bead Panel, containing 5 biomarkers. This kit may be used for the analysis of all or any combination of the above analytes in tissue/cell lysate/culture supernatant samples and cerebrospinal fluid (CSF). Serum or plasma samples may also be used, and will need to be extracted, however we do not recommend using the panel for serum and plasma Substance P. The kit contains enough material to analyze 38 samples in duplicate, including the standard curve and two quality controls.
An important note about this panel is that the samples may be extracted using either the acetonitrile precipitation technique or the Waters 96-well HLB extraction plate. Please refer to the protocol for more information on both methods. The necessary components to perform the extractions are not included with the kit.
The central nervous system is a complex environment consisting of billions of neurons as well as glial support cells. These neurons use many different chemical signals to communicate information, including neurotransmitters, cannabinoids, peptides, and gases such as nitric oxide. Neuropeptides are secreted primarily from the central and peripheral nervous systems, exerting a broad spectrum of biological functions that includes the regulation of metabolism, reproduction, and immunity.
Panel Type: Neuroscience
An important note about this panel is that the samples may be extracted using either the acetonitrile precipitation technique or the Waters 96-well HLB extraction plate. Please refer to the protocol for more information on both methods. The necessary components to perform the extractions are not included with the kit.
The central nervous system is a complex environment consisting of billions of neurons as well as glial support cells. These neurons use many different chemical signals to communicate information, including neurotransmitters, cannabinoids, peptides, and gases such as nitric oxide. Neuropeptides are secreted primarily from the central and peripheral nervous systems, exerting a broad spectrum of biological functions that includes the regulation of metabolism, reproduction, and immunity.
Panel Type: Neuroscience
Application
- Analytes: α-MSH, β-Endorphin, Neurotensin, Oxytocin, Substance P.
- Recommended Sample type: serum, plasma, CSF, and tissue culture
- Recommended Sample dilution: This assay requires 50 μL extracted serum or plasma sample per well or 50 μL neat CSF or culture media per well
- Assay Run Time: Overnight
- NOTE: this is a competitive assay.
Features and Benefits
Design your multiplex kit by choosing available analytes within this panel.
Other Notes
Sensitivity: Refer to kit protocol for sensitivities of individual biomarkers.
Legal Information
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Certificates of Analysis (COA)
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Willem J van den Brink et al.
The AAPS journal, 19(1), 274-285 (2016-10-28)
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Many psychiatric illnesses have a multifactorial etiology involving genetic and environmental risk factors that trigger persistent neurodevelopmental impairments. Several risk factors have been individually replicated in rodents, to understand disease mechanisms and evaluate novel treatments, particularly for poorly-managed negative and
Jorge Moreno-Fernández et al.
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Iron deficiency anemia (IDA) is one of the most prevalent nutritional deficiencies worldwide. Iron plays critical roles in nervous system development and cognition. Despite the known detrimental consequences of IDA on cognition, available studies do not provide molecular mechanisms elucidating
Willem J van den Brink et al.
British journal of pharmacology, 175(19), 3832-3843 (2018-07-28)
Because biological systems behave as networks, multi-biomarker approaches increasingly replace single biomarker approaches in drug development. To improve the mechanistic insights into CNS drug effects, a plasma neuroendocrine fingerprint was identified using multi-biomarker pharmacokinetic/pharmacodynamic (PK/PD) modelling. Short- and long-term D2
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