937258
NanoFabTx™ for gene delivery
Folate lipid mix
Synonym(s):
Cholesterol, DMG-PEG, DODMA, DOPE, DOTMA, DSPE-PEG-Folate
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About This Item
UNSPSC Code:
12352142
NACRES:
NA.21
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Quality Level
storage temp.
−20°C
General description
Folate lipid mix for gene delivery and targeted delivery
The NanoFabTx™ gene delivery folate lipid mix is a ready-to-use nanoformulation lipid mixture for the synthesis of folate-functionalized lipid nanoparticles (LNPs).These lipid nanoparticles can be used for targeted drug delivery of nucleic acids for a wide range of applications including cancer treatment.
This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of lipid nanoparticles. Step-by-step protocols for the synthesis of maleimide-functionalized LNPs by microfluidics with the NanoFabTx™ microfluidic- nano device kit (Cat. No. 911593) or nanoprecipitiation are included.
The overexpression of folate receptors on tumor cells is common in many different cancers, making folate a suitable targeting ligand for targeted drug delivery. Folate conjugated nanoparticles and LNPs have been used for the delivery of a variety of chemotherapies and radiodiagnostic imaging agents for cancer treatment and diagnostics. The NanoFabTx(TM) gene delivery folate lipid mix can specifically be used to prepare folate-functionalized LNPss for the delivery of novel gene therapeutics such as mRNA and siRNA.
This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of lipid nanoparticles. Step-by-step protocols for the synthesis of maleimide-functionalized LNPs by microfluidics with the NanoFabTx™ microfluidic- nano device kit (Cat. No. 911593) or nanoprecipitiation are included.
The overexpression of folate receptors on tumor cells is common in many different cancers, making folate a suitable targeting ligand for targeted drug delivery. Folate conjugated nanoparticles and LNPs have been used for the delivery of a variety of chemotherapies and radiodiagnostic imaging agents for cancer treatment and diagnostics. The NanoFabTx(TM) gene delivery folate lipid mix can specifically be used to prepare folate-functionalized LNPss for the delivery of novel gene therapeutics such as mRNA and siRNA.
Application
With the NanoFabTx™ gene delivery folate lipid mix, researchers can simplify their drug development workflow. The ready to use mix enables the screening of different drug modalities such as nucleic acids (mRNA, DNA, siRNA), and vaccines without the need to develop new drug delivery formulations from scratch, ultimately speeding up the time it takes for innovative therapeutics to go from the bench to the clinic. The folate-functionalized LNPs can be used to target tumor and other cells that overexpress the folate receptor. This ready to use lipid mix can be used to screen a variety of different therapeutics and explore active targeting in early-stage drug discovery and development. In addition, the lipid mix has been carefully curated for enhanced nucleic acid delivery for a wide range of applications including oncology and immunotherapy.
advanced drug delivery
Features and Benefits
- A ready-to-use nanoformulation lipid blend for the synthesis of folate-functionalized lipid nanoparticles
- Step-by-step microfluidics protocols developed and tested by our formulation scientists
- Flexible synthesis methods to create uniform and reproducible lipid nanoparticles
- Protocols and lipid blend optimized to synthesize lipid nanoparticles around 100 nm with low polydispersity
- Lipid mix optimized for folate-functionalized lipid nanoparticles for mRNA encapsulation
- For more information, please refer to the protocol under the document section of this page.
Legal Information
Legal Information NanoFabTx is a trademark of Sigma-Aldrich Co. LLC
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
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Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts
Yoshizawa T, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 70(3), 718-725 (2008)
Targeted delivery of nucleic acids into xenograft tumors mediated by novel folate-equipped liposomes
Kabilova T, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 123, 59-70 (2018)
Microfluidic self-assembly of folate-targeted monomolecular siRNA-lipid nanoparticles.
Krzyszton R, et al.
Nanoscale, 9(22), 7442-7453 (2017)
Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration
Muralidharan R, et al.
Journal of Nanobiotechnology, 14(1), 47-47 (2016)
Design of Folate-Containing Liposomal Nucleic Acid Delivery Systems for Antitumor Therapy
Shmendel E, et al.
Pharmaceutics, 15(5), 1400-1400 (2023)
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