- Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine.
Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine.
Chemical communications (Cambridge, England) (2013-07-19)
Jian Zheng, Ji Cai, Jin-Hong Lin, Yong Guo, Ji-Chang Xiao
PMID23863949
ABSTRACT
A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its reactivity could be adjusted by the modification of the substituent on the phosphorus.