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Key Documents

SAB4500194

Sigma-Aldrich

Anti-ERD22 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ELP-1, ER lumen protein retaining receptor 2, ERD2-like protein 1, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 24 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

P33947

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ERD22(11014)

General description

Anti-ERD22 Antibody detects endogenous levels of total ERD22 protein.
ERD22 (ER lumen protein retaining receptor 2) is also known as KDEL (endoplasmic reticulum protein retention receptor 1). It codes for a a 26kDa integral membrane protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human ERD22.

Immunogen Range: 81-130

Biochem/physiol Actions

ERD22 (ER lumen protein retaining receptor 2) is essential for retention. It is redistributed from the Golgi apparatus to the endoplasmic reticulum (ER) due to higher expression of KDEL (endoplasmic reticulum protein retention receptor 1) .Mutation of hERD2 changes the specificity of ligand and communicate directly with the retained proteins.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum
Lewis MJ and Pelham HR
Cell, 68(2), 353-364 (1992)
ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway
Semenza JC, et al.
Cell, 61(7), 1349-1357 (1990)

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