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M0500000

Mepyramine maleate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Pyrilamine maleate salt, Mepyramine maleate salt, N-(4-Methoxyphenyl)methyl-N′,N′-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt

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About This Item

Empirical Formula (Hill Notation):
C17H23N3O · C4H4O4
CAS Number:
59-33-6
Molecular Weight:
401.46
MDL number:
MFCD00069333
UNSPSC Code:
41116107
PubChem Substance ID:
329817794
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

pyrilamine, mepyramine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1

InChI

1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

JXYWFNAQESKDNC-BTJKTKAUSA-N

Gene Information

human ... HRH1(3269)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Mepyramine maleate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Central hypertensive action of histamine in conscious normotensive cats.
Finch L, et al.
European Journal of Pharmacology, 36(1), 263-266 (1976)
High-performance liquid chromatographic determination of mepyramine maleate, pheniramine maleate and phenylpropanolamine hydrochloride in tablets and drops.
El-Gizawy S M, et al.
Analyst, 112(6), 867-869 (1987)
Lingli Yang et al.
The Journal of investigative dermatology, 134(8), 2105-2113 (2014-03-01)
Histamine is thought to have a critical role in the synthesis of extracellular matrix in skin and may be involved in tissue remodeling of allergic diseases. Recent studies revealed that periostin, a matricelluar protein, contributed to tissue remodeling; however, a
Rhys L Evans et al.
Experimental lung research, 41(4), 189-198 (2015-04-07)
Asthma is associated with reversible airway obstruction, leucocyte infiltration, airways hyperresponsiveness (AHR), and airways remodeling. Fluid accumulation causes pulmonary edema contributing to airways obstruction. We examined the temporal relationship between the late asthmatic response (LAR) following allergen challenge of sensitized
Hong Wei et al.
Pharmacological research, 90, 58-66 (2014-10-12)
Among brain structures receiving efferent projections from the histaminergic tuberomammillary nucleus is the pontine locus coeruleus (LC) involved in descending noradrenergic control of pain. Here we studied whether histamine in the LC is involved in descending regulation of neuropathic hypersensitivity.
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