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  • The effects of poly(zwitterions)s versus poly(ethylene glycol) surface coatings on the biodistribution of protein nanoparticles.

The effects of poly(zwitterions)s versus poly(ethylene glycol) surface coatings on the biodistribution of protein nanoparticles.

Biomaterials science (2016-07-19)
Jing Wang, Shanmei Yuan, Yajun Zhang, Wei Wu, Yong Hu, Xiqun Jiang
ABSTRACT

Zwitterionic poly(carboxybetaine) (PCB), poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and non-ionic poly(ethylene glycol) (PEG), which have similar degrees of polymerization, were grafted to branched polyethyleneimine (PEI) to generate PCB-grafted PEI (PEI-PCB), PMPC-grafted PEI (PEI-PMPC) and PEG-grafted PEI (PEI-PEG) copolymers, respectively. These grafted PEI copolymers with almost the same grafting number were coated on the surface of 110 nm bovine serum albumin-poly(N-3-acrylamidophenylboronic acid) (BSA-PAPBA) nanoparticles to make a comparison of the surface decoration effect on the biodistribution of nanoparticles. Compared to the nanoparticles without surface decoration, surface decoration with the copolymers significantly prolonged the circulation time of BSA-PAPBA nanoparticles, leading to remarkable enhancement of tumor uptake of the nanoparticles. The drug accumulation at the tumor site reached more than 10% injected dose per gram of tumor. Among them, the PEI-PMPC-decorated nanoparticles exhibited the best performance in tumor accumulation and anticancer ability. Thus, these surface-decorated nanoparticles may serve as a strong candidate for high tumor accumulation of drug delivery systems.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Branched PEI-g-PEG, PEG Mn 550
Sigma-Aldrich
NanoFabTx PEG-PEI, for gene delivery
Sigma-Aldrich
Branched PEI-g-PEG, PEG Mn 5,000