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Key Documents

SAB4500130

Sigma-Aldrich

Anti-Centromeric Protein A antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CENA, CENP-A, CENPA, Centromere autoantigen A, Centromere protein A

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 15 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CENPA(1058)

Related Categories

General description

Anti-Centromeric protein A Antibody detects endogenous levels of total Centromeric protein A protein.
Centromeric Protein A (CENPA), is encoded by the gene mapped to human chromosome 2p23.3. The encoded protein is a longer variant of histone H3 in humans.

Immunogen

The antiserum was produced against synthesized peptide derived from human Centromeric Protein A.

Immunogen Range: 1-50

Biochem/physiol Actions

Centromeric Protein A (CENPA) plays a vital role in centromere specification and facilitates its mitotic function and epigenetic maintenance. CENP-A-nucleosome associated complex (NAC) is implicated in the regulation of chromosome congression and spindle bipolarity. Disorganization of this complex leads to change in chromosome alignment and segregation that prevent cell survival regardless of continued centromere-derived mitotic checkpoint signaling.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The CENP?A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity
McClelland S E, et al.
The Embo Journal, 26(24), 5033-5047 (2007)
A dual inhibitory mechanism sufficient to maintain cell cycle restricted CENP-A assembly
Stankovic A, et al.
Molecular Cell, 65(2), 231-246 (2017)
The human CENP-A centromeric nucleosome-associated complex
Foltz D R, et al.
Nature Cell Biology, 8(5), 458-458 (2006)
CENP-A modifications on Ser68 and Lys124 are dispensable for establishment, maintenance, and long-term function of human centromeres
Fachinetti D, et al.
Developmental Cell, 40(1), 104-113 (2017)
A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.
Sadakierska-Chudy A
Neurotoxicity Research, 27(1), 84-97 (2015)

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