T-911
α-Hydroxytriazolam solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C17H12Cl2N4O
CAS Number:
Molecular Weight:
359.21
EC Number:
UNSPSC Code:
41116107
NACRES:
NA.24
Recommended Products
grade
certified reference material
Quality Level
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
2-8°C
SMILES string
OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12
InChI
1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2
InChI key
BHUYWUDMVCLHND-UHFFFAOYSA-N
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General description
a-Hydroxytriazolam is a major urinary and blood metabolite of the benzodiazepine, triazolam, a pharmaceutical used to treat severe insomnia. This certified solution standard is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pharmaceutical research.
Application
- Pharmacokinetic analysis of benzodiazepines: alpha-Hydroxytriazolam solution is employed in the quantitation of benzodiazepines and their metabolites in biological fluids using liquid chromatography-tandem mass spectrometry, providing accurate pharmacokinetic profiles that are essential for clinical and forensic analysis (Zheng et al., 2018).
- Receptor binding studies: The application of high-purity alpha-Hydroxytriazolam in receptor binding studies enables researchers to elucidate the interaction mechanisms of benzodiazepine analogs at the molecular level, thereby enhancing the understanding of their pharmacological effects (Minegishi et al., 2021).
- Development of analytical methods: alpha-Hydroxytriazolam solution serves as a critical analytical standard in the development of robust assays for the detection and quantification of benzodiazepines in various matrices, facilitating advancements in toxicological and pharmacological research (Lahr et al., 2020).
- Forensic and clinical toxicology: Utilized in forensic science, alpha-Hydroxytriazolam solution aids in the rapid determination of benzodiazepines and their metabolites in urine samples, crucial for the accurate interpretation of toxicological data (Jeong et al., 2015).
- Scientific research in biochemistry: alpha-Hydroxytriazolam research compounds are vital for studying the metabolic pathways and degradation profiles of triazolam and related benzodiazepines, supporting biochemists in drug metabolism and pharmacokinetics research (Jin et al., 2011).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
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Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes,Central nervous system
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
49.5 °F - closed cup
Flash Point(C)
9.7 °C - closed cup
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Customers Also Viewed
P Coassolo et al.
Journal of chromatography, 274, 161-170 (1983-05-13)
A gas--liquid chromatographic method for the simultaneous determination of triazolam and its major hydroxy metabolite (1-hydroxymethyltriazolam) in human plasma and urine is described. After addition of two internal standards to the biological fluid, extraction at pH 9, acid washing, back-extraction
W J Adams et al.
Journal of pharmaceutical sciences, 72(10), 1185-1189 (1983-10-01)
The absorption of triazolam from pelleted drug-diet mixtures by mice under steady-state conditions was determined for doses up to 150 mg/kg/day by measuring alpha-hydroxytriazolam, the principal urinary metabolite of triazolam in the mouse, in urine samples collected over a 24-hour
O Dehlin et al.
European journal of clinical pharmacology, 25(1), 91-94 (1983-01-01)
Serum triazolam levels were determined in eight geriatric patients (average age 80 years) on Days 1 and 7 of administration of triazolam 0.25 mg once daily, 1 h after a standard breakfast. Triazolam was rapidly absorbed reaching average peak concentrations
Barry Levine et al.
Journal of analytical toxicology, 26(1), 52-54 (2002-03-13)
The case of a 77-year-old woman who was found dead in her bathtub with her head clearly above the water line is presented. The decedent had a medical history of depression, liver disease, spinal stenosis, and diabetes mellitus. An empty
Kenji Tsujikawa et al.
Journal of analytical toxicology, 29(4), 240-243 (2005-06-25)
The objective of this study was to examine urinary excretion profiles of two major triazolam metabolites, alpha-hydroxytriazolam (alpha-OHTRZ) and 4-hydroxytriazolam (4-OHTRZ) in humans. Urine samples were collected from three healthy male volunteers who had been previously administered single 0.25- and
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