- Effect of endosomal acidification on small ion transport through the anthrax toxin PA
Effect of endosomal acidification on small ion transport through the anthrax toxin PA
FEBS letters (2017-10-01)
Nnanya Kalu, Antonio Alcaraz, Goli Yamini, Sanaz Momben Abolfath, Laura Lucas, Clare Kenney, Vicente M Aguilella, Ekaterina M Nestorovich
PMID28963849
ABSTRACT
Tight regulation of pH is critical for the structure and function of cells and organelles. The pH environment changes dramatically along the endocytic pathway, an internalization transport process that is 'hijacked' by many intracellularly active bacterial exotoxins, including the anthrax toxin. Here, we investigate the role of pH on single-channel properties of the anthrax toxin protective antigen (PA
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