- Hydrogen bond templated 1:1 macrocyclization through an olefin metathesis/hydrogenation sequence.
Hydrogen bond templated 1:1 macrocyclization through an olefin metathesis/hydrogenation sequence.
Organic letters (2013-07-09)
Andrada Stefania Trita, Thierry Roisnel, Florence Mongin, Floris Chevallier
PMID23829609
ABSTRACT
The construction of pyridine-containing macrocyclic architectures using a nonmetallic template is described. 4,6-Dichlororesorcinol was used as an exotemplate to self-organize two aza-heterocyclic units by OH···N hydrogen bonds. Subsequent sequential double olefin metathesis/hydrogenation reactions employing a single ruthenium-alkylidene precatalyst open access to macrocyclic molecules.
MATERIALS