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  • Rhodium-catalyzed conversion of furans to highly functionalized pyrroles.

Rhodium-catalyzed conversion of furans to highly functionalized pyrroles.

Journal of the American Chemical Society (2013-03-13)
Brendan T Parr, Samantha A Green, Huw M L Davies
PMID23477809
ABSTRACT

The synthesis of highly functionalized pyrroles has been achieved by reaction of rhodium-stabilized imino-carbenes with furans. The reaction features an initial [3+2] annulation to form bicyclic hemiaminals, followed by ring opening to generate trisubstituted pyrroles.

MATERIALS
Product Number
Brand
Product Description
204218
Sigma-Aldrich
Rhodium, powder, 99.95% trace metals basis
357340
Sigma-Aldrich
Rhodium, foil, thickness 0.025 mm, 99.9% trace metals basis