Skip to Content
Merck
  • Multifunctional Fe3O4-TiO2 nanocomposites for magnetic resonance imaging and potential photodynamic therapy.

Multifunctional Fe3O4-TiO2 nanocomposites for magnetic resonance imaging and potential photodynamic therapy.

Nanoscale (2013-02-06)
Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Jianjun Zheng, Bin Chen, Aiguo Wu
PMID23381832
ABSTRACT

Multifunctional Fe(3)O(4)-TiO(2) nanocomposites with Janus structure for magnetic resonance imaging (MRI) and potential photodynamic therapy (PDT) were synthesized, in which Fe(3)O(4) was used as a MRI contrast agent and TiO(2) as an inorganic photosensitizer for PDT. Their morphology, structure, and MRI and PDT performance were characterized, respectively. Moreover, the location of Fe(3)O(4)-TiO(2) nanocomposites in MCF-7 cells was also investigated by the staining of Prussian blue and alizarin red, respectively. The results showed that the as-prepared Fe(3)O(4)-TiO(2) nanocomposites had good T(2)-weighted MRI performance, and the MCF-7 cells incubated with nanocomposites could be killed under the irradiation of UV light. Compared with traditional organic photosensitizers, TiO(2) inorganic photosensitizers could have more stable PDT performance due to their nanoscale size and anti-photodegradable stability. Therefore, the as-prepared Fe(3)O(4)-TiO(2) nanocomposites could have potential applications as a new kind of multifunctional agent for both MRI and PDT.

MATERIALS
Product Number
Brand
Product Description
310069
Sigma-Aldrich
Iron(II,III) oxide, powder, <5 μm, 95%
700312
Sigma-Aldrich
Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size, 5 mg/mL in toluene
700320
Sigma-Aldrich
Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size, 5 mg/mL in toluene
725331
Sigma-Aldrich
Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size, 5 mg/mL in H2O
725358
Sigma-Aldrich
Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size, 5 mg/mL in H2O
518158
Sigma-Aldrich
Iron(II,III) oxide, 99.99% trace metals basis
637106
Sigma-Aldrich
Iron(II,III) oxide, nanopowder, 50-100 nm particle size (SEM), 97% trace metals basis
700304
Sigma-Aldrich
Iron oxide(II,III), magnetic nanoparticles solution, 20 nm avg. part. size, 5 mg/mL in toluene
725366
Sigma-Aldrich
Iron oxide(II,III), magnetic nanoparticles solution, 20 nm avg. part. size, 5 mg/mL in H2O