- Cyclopropane compatibility with oxidative carbocation formation: total synthesis of clavosolide A.
Cyclopropane compatibility with oxidative carbocation formation: total synthesis of clavosolide A.
Organic letters (2012-10-26)
GuangRong Peh, Paul E Floreancig
PMID23095114
ABSTRACT
Cyclopropane-substituted allylic ethers react with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to form oxocarbenium ions with no competitive ring cleavage. This reaction can be used for the preparation of cyclopropane-substituted tetrahydropyrans. The protocol was used as a key step in the total synthesis of the sponge-derived macrolide clavosolide A.
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