- Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst.
Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst.
Organic & biomolecular chemistry (2006-05-27)
Tian-Yu Liu, Jun Long, Bang-Jing Li, Lin Jiang, Rui Li, Yong Wu, Li-Sheng Ding, Ying-Chun Chen
PMID16729123
ABSTRACT
The bifunctional thiourea-tertiary amine derivatives of simple chiral diamines serve as highly enantioselective catalysts for the Michael addition of alpha-substituted cyanoacetates to vinyl sulfones, giving an efficient protocol for the construction of an all-carbon substituted quaternary stereocentre.
MATERIALS