Lower nitric oxide susceptibility of trivalent antimony-resistant amastigotes of Leishmania infantum.

Lower nitric oxide susceptibility of trivalent antimony-resistant amastigotes of Leishmania infantum.

Antimicrobial agents and chemotherapy (2005-09-29)

P Holzmuller, D Sereno, J-L Lemesre

ABSTRACT

We previously documented the induction of Leishmania amastigote apoptosis by trivalent antimony (SbIII) and nitric oxide (NO). We demonstrate here that SbIII-resistant amastigotes were resistant to NO toxicity when delivered extracellularly by NO donors or intracellularly via macrophage activation. Shared biochemical targets for SbIII and NO resistance in Leishmania are discussed.

MATERIALS

Product Number

Brand

Product Description

60063

Sigma-Aldrich

Potassium antimonyl tartrate trihydrate, purum p.a., 99.0-103% (RT)

Pricing and availability is not currently available.

11126

Sigma-Aldrich

Potassium antimonyl tartrate trihydrate, puriss., meets analytical specification of USP, 99.0-103.0%, powder

Pricing and availability is not currently available.

383376

Sigma-Aldrich

Potassium antimonyl tartrate trihydrate, ACS reagent, ≥99%

Pricing and availability is not currently available.