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  • Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

Nature structural & molecular biology (2011-11-15)
Ivan V Rosado, Frédéric Langevin, Gerry P Crossan, Minoru Takata, Ketan J Patel
ABSTRACT

Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that can damage DNA. Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA) DNA-repair pathway. These results define a fundamental role for the combined action of formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Formaldehyde Dehydrogenase from Pseudomonas sp., lyophilized powder, 1.0-6.0 units/mg solid