- Preparation of neutron-activatable holmium nanoparticles for the treatment of ovarian cancer metastases.
Preparation of neutron-activatable holmium nanoparticles for the treatment of ovarian cancer metastases.
Small (Weinheim an der Bergstrasse, Germany) (2012-02-03)
Anthony J Di Pasqua, James E Huckle, Jin-Ki Kim, Younjee Chung, Andrew Z Wang, Michael Jay, Xiuling Lu
PMID22298503
ABSTRACT
Nanoparticles containing stable holmium ((165) Ho) are prepared by nanotemplate engineering and subsequently irradiated in a neutron flux to yield (166) Ho, a beta-emitting radiotherapeutic isotope. After intraperitoneal injection to mice bearing SKOV-3 ovarian tumors, significant tumor accumulation of the (166) Ho-nanoparticles is observed by SPECT imaging indicating the potential of these neutron activatable nanoparticles for internal radiation therapy of ovarian cancer metastases.